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(More customer reviews)Why would adipocyte/adipose tissue secretory products predict weight gain, when as a whole, they are the consequence, not the cause of acquired obesity? Why would insulin resistance predict weight gain when weight gain, under the lifestyle model of type 2 diabetes onset, is the cause - not the consequence of target tissue insulin resistance? Why not explain the role of adipogenesis fully and completely? And if insulin resistance (at the adipocyte) occurs along (side-by-side) with some measure of heritable obesity due to genetic/congenital/programming factors, acquired obesity per se would probably not be concerning. Why is there not a single paragraph on the treatment of adipocyte cellularity and adipocyte size? Why is there no discussion of adipocyte hypertrophy (the cause and consequence of adipocyte size) or hyperplasia (the cause and consequence of adipose cellularity) - That is, the proliferation and differentiation of new adipocytes in adults under a variety of circumstances (eg, some oral anti-diabetic meds?) Why on earth are the ligand agonists (TZD's) of PPAR-gamma only mentioned in relation to "fat redistribution" when in fact, PPAR-gamma is considered a key regulator in adipogenesis? Why not discuss PPAR-gamma fully and then provide information on ligand activation. This very incomplete discussion makes it appear as if visceral fat magically moves to subcutaneous regions, and voila, insulin sensitivity returns! Why is insulin sensitivity improved? Why no discussion? Why is insulin resistance explicitly mentioned as a problem only for liver and skeletal glucose uptake, when the majority of excess energy uptake occurs at the adipocyte? I could go on and on, but suffice to say, in my humble opinion, this book seriously lacks the most basic anatomic, physiologic, and biologic foundation to intelligently address, research, and interpret the problem(s) of obesity in populations. Why so many important aspects of the obesity discussion were ignored or left out is unclear and concerning. It makes no sense. For new students to the topic, this book will not bring them closer to understanding obesity. It will definitely confuse, more than enlighten, but they probably won't even know. For students who are up to date on the obesity literature, they will most certainly feel as I do.
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During the past twenty years there has been a dramatic increase in obesity in the United States.An estimated thirty percent of adults in the US are obese; in 1980, only fifteen percent were.The issue is gaining greater attention with the CDC and with the public health world in general. This book will offer practical information about the methodology of epidemiologic studies of obesity, suitable for graduate students and researchers in epidemiology, and public health practitioners with an interest in the issue. The book will be structured in four main sections, with the majority of chapters authored by Dr. Hu, and some authored by specialists in specific areas.The first section will consider issues surrounding the definition of obesity, measurement techniques, and the designs of epidemiologic studies. The second section will address the consequences of obesity, looking at epidemiologic studies that focus on cardio-vascular disease, diabetes, and cancerThe third section will look at determinants obesity, reviewing a wide range of risk factors for obesity including diet, physical activity and sedentary behaviors, sleep disorders, psychosocial factors, physical environment, biochemical and genetic predictors, and intrauterine exposures.In the final section, the author will discuss the analytical issues and challenges for epidemiologic studies of obesity.
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